Is the expression of classical HLA class I antigens on trophoblast of importance for human pregnancy?

doi:10.1111/j.1600-0897.1998.tb00407.x

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Article

Is the expression of classical HLA class I antigens on trophoblast of importance for human pregnancy?

American journal of reproductive immunology (New York, N.Y. : 1989) - 1 Sept 1998

Christiansen O B, Mohapeloa H P, Pedersen B, Rosgaard A

Abstract excerpt

PROBLEM: Human leukocyte antigen (HLA)-C and possibly also HLA-B seem to be expressed on the extravillous trophoblast. These antigens carry epitopes that function as ligands for natural killer (NK)-cell-inhibitory receptors. Antitrophoblast cytotoxicity mediated by decidual NK cells might be invo...

Topics

Abortion, Habitual
Adult
Alleles
Female
HLA-B Antigens
HLA-C Antigens
Humans
Killer Cells, Natural
Male
Pregnancy
Trophoblasts

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