Article
Paternal HLA-C is a risk factor in unexplained recurrent miscarriage.
American journal of reproductive immunology (New York, N.Y. : 1989) - 1 Feb 2018
Meuleman Tess, Haasnoot Geert W, van Lith Jan M M, Verduijn Willem, Bloemenkamp Kitty W M, Claas Frans H J
Abstract excerpt
PROBLEM: HLA-C is the only classical HLA-I antigen expressed on trophoblast. We hypothesized that the alloimmune response to paternal HLA-C plays a role in unexplained recurrent miscarriage. METHOD OF STUDY: In a case-control design, we included 100 women with at least three unexplained consecutive miscarriages along with their partners and children. For the first control group, we included 90 women with an...
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