Article
Molecular analysis of the BRCA2 gene in 16 breast/ovarian cancer Spanish families.
Clinical genetics - 1 Aug 1998
Osorio A, Robledo M, Martínez B, Cebrián A, San Román J M, Albertos J, Lobo F, Benítez J
Abstract excerpt
The recent isolated gene BRCA2 is responsible for about 45% of familial breast cancer and the majority of male breast cancer families. In order to evaluate the role of inherited BRCA2 mutations in Spanish families, the complete coding sequence of the gene was screened by SSCP/sequencing in 16 hig...
Topics
- Adult
- BRCA2 Protein
- Breast Neoplasms
- Breast Neoplasms, Male
- DNA Mutational Analysis
- Female
- Genotype
- Haplotypes
- Humans
- Male
- Middle Aged
- Neoplasm Proteins
- Ovarian Neoplasms
- Pedigree
- Phenotype
- Polymorphism, Restriction Fragment Length
- Spain
- Transcription Factors