Mutation analysis of the BRCA2 gene in breast/ovarian cancer Spanish families: identification of two new mutations.

Abstract excerpt

The recently isolated gene BRCA2 is responsible for about 45% of familial breast cancer and the majority of male breast cancer families. We have screened 12 high risk breast/ovarian Spanish families for mutations in BRCA2, using SSCP followed by direct sequencing. We have found mutations in four...

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