Article
Activation of CD4+ and CD8+ parasite -specific T-cells by macrophages infected with live T. cruzi amastigotes.
Immunology letters - 1 Sept 1998
Caulada-Benedetti Z, Vecchio L C, Pardi C C, Massironi S M, D'Império Lima M R, Abrahamsohn I A
Abstract excerpt
T. cruzi-infected macrophages are potential candidates for the presentation of parasite antigens to T. cruzi-specific T lymphocytes. To assess this question, we examine the ability of peritoneal exudate macrophages to process exogenous live or dead parasites and to activate defined populations of T. cruzi-specific immune T-cells. Macrophages infected with live amastigotes activated both lymph node CD4+ and spleen...
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