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Article

Autosomal dominant nocturnal frontal-lobe epilepsy: genetic heterogeneity and evidence for a second locus at 15q24.

American journal of human genetics - 1 Oct 1998

Phillips H A, Scheffer I E, Crossland K M, Bhatia K P, Fish D R, Marsden C D, Howell S J, Stephenson J B, Tolmie J, Plazzi G, Eeg-Olofsson O, Singh R, Lopes-Cendes I, Andermann E, Andermann F, Berkovic S F, Mulley J C

Abstract excerpt

Autosomal dominant nocturnal frontal-lobe epilepsy (ADNFLE) is a recently identified partial epilepsy in which two different mutations have been described in the alpha4 subunit of the neuronal nicotinic acetylcholine receptor (CHRNA4). An additional seven families are presented in which ADNFLE is unlinked to the CHRNA4 region on chromosome 20q13.2. Seven additional sporadic cases showed no evidence of defective...

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Source

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Identifiers

PMID: 9758605
DOI: 10.1086/302047
PMCID: PMC1377480

Genes

CHRNA4
CHRNA3
CHRNA5
CHRNB4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Autosomal dominant nocturnal frontal-lobe epilepsy: genetic heterogeneity and evidence for a second locus at 15q24.PMID 9758605Read ↗

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Evidence for a fourth locus for autosomal dominant nocturnal frontal lobe epilepsy.Semantic proximity Read ↗

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