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Article

A major role of the nicotinic acetylcholine receptor gene CHRNA2 in autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is unlikely.

Neuroscience letters - 5 Jul 2007

Gu Wenli, Bertrand Daniel, Steinlein Ortrud K

Abstract excerpt

Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is known to be caused by mutations in the transmembrane regions of the neuronal nicotinic acetylcholine receptor (nAChR) genes CHRNA4 and CHRNB2. A third nAChR gene, CHRNA2, has been recently reported as mutated in an Italian family with nocturnal frontal lobe epilepsy, nocturnal wandering and ictal fear. We have now evaluated the role of CHRNA2 in...

Topics

Chromosome Disorders
Epilepsy, Frontal Lobe
Fear
Humans
Mutation
Phenotype
Receptors, Nicotinic
Reverse Transcriptase Polymerase Chain Reaction

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 17602836
DOI: 10.1016/j.neulet.2007.06.006

Genes

CHRNA2
CHRNA4
CHRNB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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A major role of the nicotinic acetylcholine receptor gene CHRNA2 in autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is unlikely.PMID 17602836Read ↗

CHRNA2 mutations are rare in the NFLE population: evaluation of a large cohort of Italian patients.Semantic proximity Read ↗

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A novel mutation of the nicotinic acetylcholine receptor gene CHRNA4 in sporadic nocturnal frontal lobe epilepsy.Semantic proximity Read ↗

Mutations in familial nocturnal frontal lobe epilepsy might be associated with distinct neurological phenotypes.Semantic proximity Read ↗

Neuronal nicotinic receptors in human epilepsy.Semantic proximity Read ↗

Mutation of CHRNA2 in a family with benign familial infantile seizures: Potential role of nicotinic acetylcholine receptor in various phenotypes of epilepsy.Semantic proximity Read ↗

A new Chrna4 mutation with low penetrance in nocturnal frontal lobe epilepsy.Semantic proximity Read ↗

Mutational analysis of nicotinic acetylcholine receptor beta2 subunit gene (CHRNB2) in a representative cohort of Italian probands affected by autosomal dominant nocturnal frontal lobe epilepsy.Semantic proximity Read ↗

Autosomal dominant nocturnal frontal lobe epilepsy--a critical overview.Semantic proximity Read ↗

Autosomal dominant nocturnal frontal lobe epilepsy with a mutation in the CHRNB2 gene.Semantic proximity Read ↗

CHRNB2 is the second acetylcholine receptor subunit associated with autosomal dominant nocturnal frontal lobe epilepsy.Semantic proximity Read ↗

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