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Article

Evidence for a fourth locus for autosomal dominant nocturnal frontal lobe epilepsy.

Brain research bulletin - 30 Jun 2004

Combi Romina, Dalprà Leda, Malcovati Massimo, Oldani Alessandro, Tenchini Maria Luisa, Ferini-Strambi Luigi

Abstract excerpt

Mutations responsible for autosomal dominant nocturnal frontal lobe epilepsy have been identified in two members of the neuronal nicotinic acetylcholine receptor gene family: CHRNA4(ENFL1 locus) and CHRNB2 (ENFL3 locus) coding for alpha4 and beta2 subunit, respectively. However, mutations in these genes account for only a minority (less than 10%) of cases. For a third ADNFLE locus (ENFL2) on chromosome 15q24 the...

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Source

Identifiers

PMID: 15245761
DOI: 10.1016/j.brainresbull.2003.12.007

Genes

CHRNA4
CHRNB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Evidence for a fourth locus for autosomal dominant nocturnal frontal lobe epilepsy.PMID 15245761Read ↗

A new locus for autosomal dominant nocturnal frontal lobe epilepsy maps to chromosome 1Semantic proximity Read ↗

Two new putative susceptibility loci for ADNFLE.Semantic proximity Read ↗

Exclusion of linkage of nine neuronal nicotinic acetylcholine receptor subunit genes expressed in brain in autosomal dominant nocturnal frontal lobe epilepsy in four unrelated families.Semantic proximity Read ↗

Autosomal dominant nocturnal frontal-lobe epilepsy: genetic heterogeneity and evidence for a second locus at 15q24.Semantic proximity Read ↗

The nicotinic receptor beta 2 subunit is mutant in nocturnal frontal lobe epilepsy.Semantic proximity Read ↗

A major role of the nicotinic acetylcholine receptor gene CHRNA2 in autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is unlikely.Semantic proximity Read ↗

Autosomal dominant nocturnal frontal lobe epilepsy--a critical overview.Semantic proximity Read ↗

Dominant partial epilepsies. A clinical, electrophysiological and genetic study of 19 European families.Semantic proximity Read ↗

Mutational analysis of nicotinic acetylcholine receptor beta2 subunit gene (CHRNB2) in a representative cohort of Italian probands affected by autosomal dominant nocturnal frontal lobe epilepsy.Semantic proximity Read ↗

Mutations in familial nocturnal frontal lobe epilepsy might be associated with distinct neurological phenotypes.Semantic proximity Read ↗

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