Article
Is there a link between African iron overload and the described mutations of the hereditary haemochromatosis gene?
British journal of haematology - 1 Sept 1998
McNamara L, MacPhail A P, Gordeuk V R, Hasstedt S J, Rouault T
Abstract excerpt
Over 80%, of Caucasian patients with hereditary haemochromatosis are homozygotes for a C282Y mutation in the HFE gene on chromosome 6. Recent evidence suggests that a genetic factor may also be involved in the pathogenesis of African iron overload, although the locus has not been described. PCR analysis of DNA from 25 southern Africans, identified by segregation analysis as having a high probability of carrying...
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