Is there a link between African iron overload and the described mutations of the hereditary haemochromatosis gene?

doi:10.1046/j.1365-2141.1998.00917.x

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Article

Is there a link between African iron overload and the described mutations of the hereditary haemochromatosis gene?

British journal of haematology - 1 Sept 1998

McNamara L, MacPhail A P, Gordeuk V R, Hasstedt S J, Rouault T

Abstract excerpt

Over 80%, of Caucasian patients with hereditary haemochromatosis are homozygotes for a C282Y mutation in the HFE gene on chromosome 6. Recent evidence suggests that a genetic factor may also be involved in the pathogenesis of African iron overload, although the locus has not been described. PCR a...

Topics

Adult
Africa
Aged
Aged, 80 and over
Black People
Female
Ferritins
Hemochromatosis
Heterozygote
Humans
Iron Overload
Male
Mutation
Polymerase Chain Reaction
White People

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