Article
Prevalence of HFE mutations in people from North Africa living in southern France.
British journal of haematology - 1 Sept 2001
Aguilar-Martinez P, Picot M C, Becker F, Boulot P, Montoya F, Mares P, Bachelard B, Henry Y, Delarbre J L, Sarda P, Schved J F
Abstract excerpt
The two main mutations of the HFE (haemochromatosis) gene, C282Y and H63D, were found previously to be rare or absent among Africans. Dried blood samples of 1276 newborns from southern France were analysed for both HFE mutations, and the origins of the four grandparents of each newborn were recorded. The allele frequency of C282Y and H63D was 3.0% +/- 0.7% and 16.9% +/- 1.5% respectively. In a subgroup of 171...
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