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Article

Levodopa Toxicity and Apoptosis

1 Sept 1998

Abstract excerpt

Many in vitro studies have shown that levodopa is a potent toxin which is lethal to various cultured neuronal and non-neuronal cells. The in vitro toxicity of levodopa is linked mainly to its auto-oxidation, which generates a variety of harmful free radical species including superoxide, hydrogen peroxide, and hydroxyl radicals, and also semiquinones and quinones produced via the dopa-melanin metabolic route. Such...

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PMID: 9749587
DOI: 10.1002/ana.410440722

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