Article
Multi-locus nonparametric linkage analysis of complex trait loci with neural networks.
Human heredity - 1 Jan 2000
Lucek P, Hanke J, Reich J, Solla S A, Ott J
Abstract excerpt
Complex traits are generally taken to be under the influence of multiple genes, which may interact with each other to confer susceptibility to disease. Statistical methods in current use for localizing such genes essentially work under single-gene models, either implicitly or explicitly. In genomic screens for complex disease genes, some of the marker loci must be in tight linkage with disease susceptibility...
Topics
- Chromosome Mapping
- Diabetes Mellitus, Type 1
- Genetic Linkage
- Genetic Predisposition to Disease
- Humans
- Neural Networks, Computer