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Article

Cyclooxygenase 2 mRNA expression in rat brain after peripheral injection of lipopolysaccharide.

Brain research - 17 Aug 1998

Quan N, Whiteside M, Herkenham M

Abstract excerpt

Inducible cyclooxygenase 2 (COX 2) converts arachidonic acid to prostaglandins, which are thought to mediate various peripheral lipopolysaccharide (LPS)-induced central effects, including generation of fever and activation of the hypothalamic-pituitary-adrenal axis. To localize prostaglandin production in the brain following peripheral LPS administration, COX 2 mRNA expression was examined by in situ...

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PMID: 9748570
DOI: 10.1016/s0006-8993(98)00402-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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