Cyclooxygenase 2 mRNA expression in rat brain after peripheral injection of lipopolysaccharide.

doi:10.1016/s0006-8993(98)00402-8

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Article

Cyclooxygenase 2 mRNA expression in rat brain after peripheral injection of lipopolysaccharide.

Brain research - 17 Aug 1998

Quan N, Whiteside M, Herkenham M

Abstract excerpt

Inducible cyclooxygenase 2 (COX 2) converts arachidonic acid to prostaglandins, which are thought to mediate various peripheral lipopolysaccharide (LPS)-induced central effects, including generation of fever and activation of the hypothalamic-pituitary-adrenal axis. To localize prostaglandin prod...

Topics

Animals
Autoradiography
Brain
Cyclooxygenase 2
Injections, Intraperitoneal
Injections, Intravenous
Isoenzymes
Lipopolysaccharides
Male
Neurons
Phenotype
Prostaglandin-Endoperoxide Synthases
RNA, Messenger
Rats
Rats, Sprague-Dawley

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