Unstable mutations and neurodegenerative disorders.

doi:10.1007/s004150050234

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Article

Unstable mutations and neurodegenerative disorders.

Journal of neurology - 1 Aug 1998

Brice A

Abstract excerpt

Trinucleotide repeat expansions are involved in an increasing number of neurodegenerative disorders. Eight disorders are caused by translated CAG expansions with sizes usually below 100-200 repeats. Expansions are observed in unrelated genes, and the threshold above which the disease becomes mani...

Topics

Friedreich Ataxia
Genotype
Humans
Introns
Mutation
Neurodegenerative Diseases
Phenotype
Protein Biosynthesis
Trinucleotide Repeat Expansion

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