Article
Expression of proto-oncogenes and gene mutation of sarcomeric proteins in patients with hypertrophic cardiomyopathy.
Circulation research - 21 Sept 1998
Kai H, Muraishi A, Sugiu Y, Nishi H, Seki Y, Kuwahara F, Kimura A, Kato H, Imaizumi T
Abstract excerpt
Several mutations of cardiac beta-myosin heavy chain (beta-MHC) gene were reported in patients with hypertrophic cardiomyopathy (HCM). Involvement of proto-oncogenes has been shown in the mechanism of experimental cardiac hypertrophy. This study sought to examine the effects of c-H-ras and c-myc...
Topics
- Adolescent
- Adult
- Aged
- Biopsy
- Cardiomyopathy, Hypertrophic
- Female
- Gene Expression
- Genes, MHC Class II
- Genes, ras
- Humans
- Male
- Middle Aged
- Muscle Proteins
- Mutation
- Myocardium
- Polymerase Chain Reaction
- Proto-Oncogene Mas
- Proto-Oncogenes