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Article

Mutation of cis-proline 207 in mitochondrial creatine kinase to alanine leads to increased acid stability.

Protein engineering - 1 Jul 1998

Forstner M, Müller A, Rognan D, Kriechbaum M, Wallimann T

Abstract excerpt

We show that the mutation of an uncharged residue far from the active site to another uncharged residue can have effects on the active site without disturbing the overall structure of the protein. Cis-proline 207 of mitochondrial creatine kinase was mutated to alanine. The mutant showed a decrease in the pH-optimum for ATP synthesis by 1.5 units while the maximum relative activity was lowered to 53% of the...

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Identifiers

PMID: 9740374
DOI: 10.1093/protein/11.7.563

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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