Down-regulation of p27 is associated with development of colorectal adenocarcinoma metastases.

doi:10.1016/S0002-9440(10)65610-6

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Article

Down-regulation of p27 is associated with development of colorectal adenocarcinoma metastases.

The American journal of pathology - 1 Sept 1998

Thomas G V, Szigeti K, Murphy M, Draetta G, Pagano M, Loda M

Abstract excerpt

The cyclin-dependent kinase inhibitor p27 is a negative regulator of the cell cycle and a potential tumor suppressor gene. Because we had previously demonstrated that loss of p27 protein is associated with aggressive behavior in colorectal adenocarcinomas, we used immunohistochemistry and in situ...

Topics

Adenocarcinoma
Aged
Cell Cycle Proteins
Colorectal Neoplasms
Cyclin-Dependent Kinase Inhibitor p27
Down-Regulation
Female
Humans
Immunoenzyme Techniques
Ki-67 Antigen
Liver Neoplasms
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microtubule-Associated Proteins

Middle Aged

Mutation

Neoplasm Staging

RNA, Messenger

Retrospective Studies

Source

Open in PubMed Open full text

Identifiers

PMID: 9736017
DOI: 10.1016/S0002-9440(10)65610-6
PMCID: PMC1853015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9736017-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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