Article
Down-regulation of p27 is associated with development of colorectal adenocarcinoma metastases.
The American journal of pathology - 1 Sept 1998
Thomas G V, Szigeti K, Murphy M, Draetta G, Pagano M, Loda M
Abstract excerpt
The cyclin-dependent kinase inhibitor p27 is a negative regulator of the cell cycle and a potential tumor suppressor gene. Because we had previously demonstrated that loss of p27 protein is associated with aggressive behavior in colorectal adenocarcinomas, we used immunohistochemistry and in situ hybridization to evaluate the potential role of alterations in p27 expression in primary and metastatic colorectal...
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