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Article

Nup154, a new Drosophila gene essential for male and female gametogenesis is related to the nup155 vertebrate nucleoporin gene.

The Journal of cell biology - 7 Sept 1998

Gigliotti S, Callaini G, Andone S, Riparbelli M G, Pernas-Alonso R, Hoffmann G, Graziani F, Malva C

Abstract excerpt

The Nup154 gene of Drosophila encodes a protein showing similarity with known nucleoporins: rat Nup155 and yeast Nup170 and Nup157. Hypomorphic mutant alleles of Nup154 affected female and male fertility, allowing investigation of the gene function in various steps of oogenesis and spermatogenesis. Nup154 was required in testes for cyst formation, control of spermatocyte proliferation and meiotic progression. In...

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Identifiers

PMID: 9732281
DOI: 10.1083/jcb.142.5.1195
PMCID: PMC2149350

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