Article
Induction of Mn SOD in human monocytes without inflammatory cytokine production by a mutant endotoxin.
The American journal of physiology - 1 Sept 1998
Tian L, White J E, Lin H Y, Haran V S, Sacco J, Chikkappa G, Davis F B, Davis P J, Tsan M F
Abstract excerpt
Endotoxin selectively induces monocyte Mn superoxide dismutase (SOD) without affecting levels of Cu,Zn SOD, catalase, or glutathione peroxidase. However, little is known about the structure-activity relationship and the mechanism by which endotoxin induces Mn SOD. In this study we demonstrated th...
Topics
- Chemokine CCL4
- Enzyme Induction
- Escherichia coli
- Humans
- Isoenzymes
- Kinetics
- Leukocytes, Mononuclear
- Lipopolysaccharides
- Macrophage Inflammatory Proteins
- Mutation
- NF-kappa B
- RNA, Messenger
- Superoxide Dismutase
- Transcription, Genetic
- Tumor Necrosis Factor-alpha