Article
Bronchial responsiveness and angiotensin-converting enzyme gene polymorphism in sarcoidosis patients.
Chest - 1 Aug 1998
Niimi T, Tomita H, Sato S, Mori T, Kawaguchi H, Sugiura Y, Matsuda R
Abstract excerpt
BACKGROUND: Angiotensin-converting enzyme (ACE) inactivates bradykinin and tachykinins, which are potent bronchoconstrictors and mediators of inflammatory reactions. It has recently been shown that an insertion (I)/deletion (D) polymorphism in the ACE gene accounts for variation in serum ACE leve...
Topics
- Adult
- Asthma
- Bronchoconstriction
- Bronchoconstrictor Agents
- Cough
- DNA
- DNA Primers
- Female
- Genotype
- Humans
- Male
- Methacholine Chloride
- Middle Aged
- Peptidyl-Dipeptidase A
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Sarcoidosis, Pulmonary