Generation of polymorphic markers tightly linked to the thymus enlargement loci by phenotype-directed representational difference analysis.

doi:10.1007/s003359900854

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Article

Generation of polymorphic markers tightly linked to the thymus enlargement loci by phenotype-directed representational difference analysis.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Sept 1998

Toyota M, Ushijima T, Suzui M, Murakumo Y, Imai K, Sugimura T, Matsuyama M

Abstract excerpt

To obtain genetic markers linked to a specific genetic locus, genomic subtraction with a DNA pool of backcross or F2 intercross animals with a specific genotype at the locus is known to be effective. To determine whether the pooling strategy is also effective for isolation of genetic markers link...

Topics

Animals
Blotting, Southern
Chromosome Mapping
Cloning, Molecular
DNA
Electrophoresis, Agar Gel
Genetic Linkage
Genetic Markers
Genotype
Inbreeding
Lod Score

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nucleic Acid Hybridization

Phenotype

Polymerase Chain Reaction

Polymorphism, Genetic

Rats

Rats, Inbred BUF

Rats, Inbred F344

Source

Open in PubMed

Identifiers

PMID: 9716658
DOI: 10.1007/s003359900854

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9716658-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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