Article
A novel PCR-based methodology to determine TAP allele frequencies in population studies.
Tissue antigens - 1 Jul 1998
Perry C L, Mijovic C H, Cockram C S, Yeung V T, Jenkins D, Barnett A H
Abstract excerpt
The TAP genes have been extensively studied as candidate susceptibility genes for autoimmune and infectious diseases. TAP1 and TAP2 have two and three polymorphic sites respectively which are used for the allele assignment following WHO nomenclature. The usual techniques employed to determine the TAP alleles cannot unequivocally ascertain the alleles present in subjects which are heterozygous at more than one...
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