Linkage of mutant alleles of CYP2C18 and CYP2C19 in a Japanese population.

doi:10.1016/s0006-2952(98)00022-7

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Article

Linkage of mutant alleles of CYP2C18 and CYP2C19 in a Japanese population.

Biochemical pharmacology - 15 Jun 1998

Kubota T, Hibi N, Chiba K

Abstract excerpt

The coincidence of mutated alleles of CYP2C18 and CYP2C19 was studied in 154 Japanese subjects. The mutant alleles of CYP2C18 studied were CYP2C18m1 (T204 --> A substitution in exon 2) and CYP2C18mFR (A-460 --> T substitution in the 5'-flanking region), and those of CYP2C19 were CYP2C19m1 (G689 -...

Topics

Alleles
Aryl Hydrocarbon Hydroxylases
Asian People
Cytochrome P-450 CYP2C19
Cytochrome P-450 Enzyme System
Female
Genetic Linkage
Genotype
Humans
Japan
Male
Mixed Function Oxygenases
Mutation
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Reference Values

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