Article
Regulation of heregulin beta1-induced differentiation in a human breast carcinoma cell line by the extracellular-regulated kinase (ERK) pathway.
Journal of cellular biochemistry - 15 Sept 1998
Lessor T, Yoo J Y, Davis M, Hamburger A W
Abstract excerpt
The AU565 breast carcinoma cell line was used to determine the role of the extracellular-regulated kinase (ERK) pathway in mediating Heregulinbeta1 (HRGbeta1)-induced mammary cell differentiation. ERK activation remained elevated for 2 h following high doses of HRG which induce differentiation. I...
Topics
- Breast Neoplasms
- Calcium-Calmodulin-Dependent Protein Kinases
- Carrier Proteins
- Cell Differentiation
- Enzyme Activation
- Enzyme Inhibitors
- Flavonoids
- Glycoproteins
- Humans
- Kinetics
- Neuregulin-1
- Phenotype
- Tumor Cells, Cultured