Article
Antitumor activity of paclitaxel (taxol) analogues on MDR-positive human cancer cells.
Anti-cancer drug design - 1 Jul 1998
Distefano M, Scambia G, Ferlini C, Gallo D, De Vincenzo R, Filippini P, Riva A, Bombardelli E, Mancuso S
Abstract excerpt
A series of newly developed paclitaxel analogues have been tested for their growth inhibitory activity on two human breast cancer cell lines, one of which expresses the MDR (multidrug resistance) phenotype. Paclitaxel (taxol) was used as a reference compound. Three new classes of taxanes were analyzed: the cephalomannine compounds, the pyrazoline derivatives and the seco-derivatives. Our results demonstrated an...
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