Article
p21 expression is increased by irradiation in esophageal squamous cell carcinoma.
The Journal of surgical research - 1 May 1998
Rigberg D A, Kim F S, Blinman T A, Cole M A, Lane J S, So J, McFadden D W
Abstract excerpt
The p21 cyclin-dependent kinase inhibitor blocks cell cycle transition and replication in response to DNA damage. Although required for p53-mediated cell cycle arrest, p21 expression can also be initiated via p53-independent pathways. This study examines the postirradiation expression of p21 in s...
Topics
- Carcinoma, Squamous Cell
- Cell Survival
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- Enzyme-Linked Immunosorbent Assay
- Esophageal Neoplasms
- Exons
- Gamma Rays
- Gene Expression
- Genes, p53
- Humans
- Introns
- Mutation
- Tumor Cells, Cultured