Article
Association of the Trp64Arg mutation of the beta3-adrenergic receptor with fatty liver and mild glucose intolerance in Japanese subjects.
Clinica chimica acta; international journal of clinical chemistry - 22 Jun 1998
Shima Y, Tsukada T, Nakanishi K, Ohta H
Abstract excerpt
The prevalence of a mutation of the codon for tryptophan 64 to arginine (Trp64Arg) in the beta3-adrenergic receptor gene was investigated by genotyping 261 Japanese subjects. The allelic frequency of this mutation was 0.18. Subjects with the homozygous W64R mutant alleles had a significantly high...
Topics
- Alleles
- Arginine
- Diabetes Mellitus, Type 2
- Fatty Liver
- Gene Frequency
- Genotype
- Glucose Intolerance
- Heterozygote
- Homozygote
- Humans
- Mutation
- Obesity
- Polymorphism, Restriction Fragment Length
- Receptors, Adrenergic, beta
- Receptors, Adrenergic, beta-3
- Tryptophan