Article
[The cytogenetic effect of cyclophosphane and the formation of active forms of oxygen in the bone marrow cells of C57Bl/6 and NZW mice].
Eksperimental'naia i klinicheskaia farmakologiia - 1 Jan 2000
Guseva N V, Durnev A D, Pleskovskaia G N, Seredenin S B
Abstract excerpt
Cytogenetic study conducted after a single intraperitoneal injection of cyclophosphane in doses of 10, 20, and 40 mg/kg showed in 1.5-2-month-old male mice that the level of bone marrow cells damaged by the mutagen was significantly higher in NZW animals than in C57Bl/6 animals. The ability to pr...
Topics
- Alkylating Agents
- Animals
- Bone Marrow Cells
- Cell Respiration
- Chromosome Aberrations
- Cyclophosphamide
- Dose-Response Relationship, Drug
- Genotype
- Luminescent Measurements
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred NZB
- Mutagens