Article
The acrodermatitis enteropathica mutation affects protein expression in human fibroblasts: analysis by two-dimensional gel electrophoresis.
The Journal of nutrition - 1 Aug 1998
Grider A, Mouat M F
Abstract excerpt
The acrodermatitis enteropathica (AE) mutation affects zinc uptake in human fibroblasts. However, the specific biochemical lesion has not been identified. We have used the technique of two-dimensional gel electrophoresis to identify protein differences in total cell lysate isolated from normal an...
Topics
- Acrodermatitis
- Adolescent
- Amino Acid Sequence
- Cells, Cultured
- Electrophoresis, Gel, Two-Dimensional
- Fibroblasts
- Humans
- Infant
- Isoelectric Point
- Male
- Molecular Sequence Data
- Molecular Weight
- Mutation
- Peptide Fragments
- Proteins
- Sequence Homology
- Trypsin
- Zinc