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Article

Site-specific mutations in the 23S rRNA gene of Helicobacter pylori confer two types of resistance to macrolide-lincosamide-streptogramin B antibiotics.

Antimicrobial agents and chemotherapy - 1 Aug 1998

Wang G, Taylor D E

Abstract excerpt

Clarithromycin resistance in Helicobacter pylori is mainly due to A-to-G mutations within the peptidyltransferase region of the 23S rRNA. In the present study, cross-resistance to macrolide, lincosamide, and streptogramin B (MLS) antibiotics (MLS phenotypes) has been investigated for several clin...

Topics

Anti-Bacterial Agents
Drug Resistance, Microbial
Helicobacter pylori
Lincosamides
Macrolides
Mutagenesis, Site-Directed
Phenotype
RNA, Ribosomal, 23S
Virginiamycin

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 9687389
DOI: 10.1128/AAC.42.8.1952
PMCID: PMC105715

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9687389-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Site-specific mutations in the 23S rRNA gene of Helicobacter pylori confer two types of resistance to macrolide-lincosamide-streptogramin B antibiotics.PMID 9687389Read ↗

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