Article
Radiation hybrid mapping of the two highly homologous human-variant pMCHL genes by PCR-SSCP.
Genome research - 1 Jul 1998
Miller C L, Thompson R C, Burmeister M
Abstract excerpt
When gene loci are very similar in sequence, as in gene families or multiple pseudogenes, it is difficult to determine the specific location of the individual genes. We show here that applying PCR-SSCP to a radiation hybrid panel allowed mapping and specific sequencing of two genes with only a few sequence differences. Human-variant forms of the promelanin-concentrating hormone (pMCH) gene are found in two...
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