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Article

Acyclovir: Discovery, mechanism of action, and selectivity

1 Jan 1993

Abstract excerpt

The reasons for acyclovir's activity and selectivity in cells infected with HSV or VZV may be summarized as follows: 1. Activation by a HSV- or VZV-specified TK. 2. Greater sensitivity of viral DNA polymerase than of the cellular polymerases to ACV-TP. 3. Inactivation of the viral DNA polymerase, but not the cellular polymerases, by ACV-TP. 4. Chain termination of viral DNA by incorporation of ACV-MP. For the...

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PMID: 8245887
DOI: 10.1002/jmv.1890410503

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