The Hansenula polymorpha per6 mutant is affected in two adjacent genes which encode dihydroxyacetone kinase and a novel protein, Pak1p, involved in peroxisome integrity.

doi:10.1007/s002940050360

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Article

The Hansenula polymorpha per6 mutant is affected in two adjacent genes which encode dihydroxyacetone kinase and a novel protein, Pak1p, involved in peroxisome integrity.

Current genetics - 1 Jul 1998

van der Klei I J, van der Heide M, Baerends R J, Rechinger K B, Nicolay K, Kiel J A, Veenhuis M

Abstract excerpt

The Hansenula polymorpha per6-210 mutant is impaired in respect of growth on methanol (Mut-) and is characterized by aberrant peroxisome formation. The functionally complementing DNA fragment contains two open reading frames. The first encodes dihydroxyacetone kinase (DAK), a cytosolic enzyme ess...

Topics

Amino Acid Sequence
Cloning, Molecular
DNA, Complementary
Fungal Proteins
Magnetic Resonance Spectroscopy
Methanol
Microbodies
Microscopy, Electron
Molecular Sequence Data
Mutation
Neurospora crassa

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Open Reading Frames

Phosphotransferases (Alcohol Group Acceptor)

Pichia

Promoter Regions, Genetic

Restriction Mapping

Sequence Analysis

Sequence Homology

Source

Open in PubMed

Identifiers

PMID: 9683670
DOI: 10.1007/s002940050360

Genes

PAK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9683670-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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The Hansenula polymorpha per6 mutant is affected in two adjacent genes which encode dihydroxyacetone kinase and a novel protein, Pak1p, involved in peroxisome integrity.PMID 9683670Read ↗

Hansenula polymorpha: an attractive model organism for molecular studies of peroxisome biogenesis and function.Semantic proximity Read ↗

Characterization of peroxisome-deficient mutants of Hansenula polymorpha.Semantic proximity Read ↗

The Hansenula polymorpha PER1 gene is essential for peroxisome biogenesis and encodes a peroxisomal matrix protein with both carboxy- and amino-terminal targeting signals.Semantic proximity Read ↗

Peroxisome biogenesis in the yeast Hansenula polymorpha is controlled by a complex set of interacting gene products.Semantic proximity Read ↗

Peroxisome biogenesis in Hansenula polymorpha: different mutations in genes, essential for peroxisome biogenesis, cause different peroxisomal mutant phenotypes.Semantic proximity Read ↗

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Selective inactivation of alcohol oxidase in two peroxisome-deficient mutants of the yeast Hansenula polymorpha.Semantic proximity Read ↗

Peroxisomes in the methylotrophic yeast Hansenula polymorpha do not necessarily derive from pre-existing organelles.Semantic proximity Read ↗

Heterologous complementation of peroxisome function in yeast: the Saccharomyces cerevisiae PAS3 gene restores peroxisome biogenesis in a Hansenula polymorpha per9 disruption mutant.Semantic proximity Read ↗

Transcriptional down-regulation of peroxisome numbers affects selective peroxisome degradation in Hansenula polymorpha.Semantic proximity Read ↗

Identification of intragenic mutations in the Hansenula polymorpha PEX6 gene that affect peroxisome biogenesis and methylotrophic growth.Semantic proximity Read ↗

Restoration of peroxisome formation in two conditional peroxisome-deficient mutants of Hansenula polymorpha during growth of cells on specific organic nitrogen sources.Semantic proximity Read ↗

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