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Article

Identification of intragenic mutations in the Hansenula polymorpha PEX6 gene that affect peroxisome biogenesis and methylotrophic growth.

FEMS yeast research - 1 Nov 2003

Stasyk Oleh V, Nazarko Volodymyr Y, Pochapinsky Olexiy D, Nazarko Taras Y, Veenhuis Marten, Sibirny Andrei A

Abstract excerpt

Two interacting AAA ATPases, Pex1p and Pex6p, are indispensable for peroxisome biogenesis in different organisms. Mutations affecting corresponding genes are the most common cause of the peroxisome biogenesis disorders in humans. By UV mutagenesis of the Hansenula polymorpha pex6 mutant, deficient in peroxisome biogenesis, we isolated a conditional cold-sensitive strain with restored ability to grow in methanol...

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Source

Identifiers

PMID: 14613878
DOI: 10.1016/S1567-1356(03)00153-3

Genes

PEX6

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of intragenic mutations in the Hansenula polymorpha PEX6 gene that affect peroxisome biogenesis and methylotrophic growth.PMID 14613878Read ↗

Mutations in the peroxin Pex26p responsible for peroxisome biogenesis disorders of complementation group 8 impair its stability, peroxisomal localization, and interaction with the Pex1p x Pex6p complex.Semantic proximity Read ↗

Hansenula polymorpha Pex1p and Pex6p are peroxisome-associated AAA proteins that functionally and physically interact.Semantic proximity Read ↗

Identification of a Homozygous PEX26 Mutation in a Heimler Syndrome Patient.Semantic proximity Read ↗

Temperature-sensitive mutation of PEX6 in peroxisome biogenesis disorders in complementation group C (CG-C): comparative study of PEX6 and PEX1.Semantic proximity Read ↗

Phenotype-genotype relationships in peroxisome biogenesis disorders of PEX1-defective complementation group 1 are defined by Pex1p-Pex6p interaction.Semantic proximity Read ↗

Temperature-sensitive mutation in PEX1 moderates the phenotypes of peroxisome deficiency disorders.Semantic proximity Read ↗

Peroxisome biogenesis and selective degradation converge at Pex14p.Semantic proximity Read ↗

PEX1 <sup>G843D</sup> remains functional in peroxisome biogenesis but is rapidly degraded by the proteasomeSemantic proximity Read ↗

Spectrum of PEX6 mutations in Zellweger syndrome spectrum patients.Semantic proximity Read ↗

The pathogenic peroxin Pex26p recruits the Pex1p-Pex6p AAA ATPase complexes to peroxisomes.Semantic proximity Read ↗

Peroxisomes in the methylotrophic yeast Hansenula polymorpha do not necessarily derive from pre-existing organelles.Semantic proximity Read ↗

A pex1 missense mutation improves peroxisome function in a subset of Arabidopsis pex6 mutants without restoring PEX5 recyclingSemantic proximity Read ↗

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