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Article

Clinical significance of MLL-AF4 fusion transcript expression in the absence of a cytogenetically detectable t(4;11)(q21;q23) chromosomal translocation.

1 Aug 1998

Abstract excerpt

Leukemic cells from bone marrow (BM) of 17 infants and 127 children with newly diagnosed ALL, as well as fetal liver and BM and normal infant BM samples, were analyzed for presence of a t(4;11) translocation using standard cytogenetic techniques and expression of an MLL-AF4 fusion transcript using standard reverse transcriptase-polymerase chain reaction (RT-PCR) assays as well as nested RT-PCR that is 100-fold...

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Identifiers

PMID: 9680349
DOI: 10.1182/blood.v92.3.810

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Clinical significance of MLL-AF4 fusion transcript expression in the absence of a cytogenetically detectable t(4;11)(q21;q23) chromosomal translocation.PMID 9680349Read ↗

The AF4·MLL fusion protein is capable of inducing ALL in mice without requirement of MLL·AF4Semantic proximity Read ↗

Bone marrow mesenchymal stem cells from infants with MLL-AF4+ acute leukemia harbor and express the MLL-AF4 fusion geneSemantic proximity Read ↗

Enforced expression of MLL-AF4 fusion in cord blood CD34+ cells enhances the hematopoietic repopulating cell function and clonogenic potential but is not sufficient to initiate leukemiaSemantic proximity Read ↗

The chromosome 4q21 gene (AF-4/FEL) is widely expressed in normal tissues and shows breakpoint diversity in t(4;11)(q21;q23) acute leukemia.Semantic proximity Read ↗

The silent mutational landscape of infant MLL-AF4 pro-B acute lymphoblastic leukemia.Semantic proximity Read ↗

The MLL recombinome of adult CD10-negative B-cell precursor acute lymphoblastic leukemia: results from the GMALL study groupSemantic proximity Read ↗

AF5q31 , a newly identified AF4 -related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23)Semantic proximity Read ↗

A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression programSemantic proximity Read ↗

LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemiasSemantic proximity Read ↗

Activated KRAS Cooperates with MLL-AF4 to Promote Extramedullary Engraftment and Migration of Cord Blood CD34+ HSPC But Is Insufficient to Initiate LeukemiaSemantic proximity Read ↗

Fusion of EML1 to ABL1 in T-cell acute lymphoblastic leukemia with cryptic t(9;14)(q34;q32).Semantic proximity Read ↗

Complex MLL rearrangements in t(4;11) leukemia patients with absent AF4.MLL fusion allele.Semantic proximity Read ↗

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