A locus in 2p13-p14 (OFC2), in addition to that mapped in 6p23, is involved in nonsyndromic familial orofacial cleft malformation.

doi:10.1006/geno.1998.5273

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Article

A locus in 2p13-p14 (OFC2), in addition to that mapped in 6p23, is involved in nonsyndromic familial orofacial cleft malformation.

Genomics - 15 Jun 1998

Pezzetti F, Scapoli L, Martinelli M, Carinci F, Bodo M, Carinci P, Tognon M

Abstract excerpt

An allelic association between the transforming growth factor alpha gene (TGFA) situated in the chromosome 2p13 region and nonsyndromic cleft lip with or without cleft palate, also named orofacial cleft (OFC), was found in several population studies. However, no linkage between gene and malformat...

Topics

Chromosomes, Human, Pair 2
Chromosomes, Human, Pair 6
Cleft Lip
Cleft Palate
Female
Genetic Heterogeneity
Genetic Markers
Genetic Variation
Humans
Italy
Linkage Disequilibrium
Lod Score
Male
Models, Genetic
Pedigree
Penetrance
Transforming Growth Factor alpha

Source

Open in PubMed

Identifiers

PMID: 9676424
DOI: 10.1006/geno.1998.5273

Genes

TGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9676424-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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