Article
LDL-receptor gene mutations and the hypocholesterolemic response to statin therapy.
Clinical genetics - 1 Jun 2001
Brorholt-Petersen J U, Jensen H K, Raungaard B, Gregersen N, Faergeman O
Abstract excerpt
Studies of the cholesterol lowering effect of statin therapy as a function of low-density lipoprotein (LDL)-receptor mutation type have not produced a clear picture, possibly because they included patients with several different kinds of LDL-receptor mutations. We studied the response to treatment with fluvastatin in 28 patients with heterozygous familial hypercholesterolemia as a result of a receptor-negative...
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