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Article

Myelin Po protein mutated at Cys21 has a dominant-negative effect on adhesion of wild type Po.

Journal of neuroscience research - 1 Jul 1998

Zhang K, Filbin M T

Abstract excerpt

The homophilic adhesion of the peripheral nervous system myelin protein, Po, holds myelin compact at the extracellular leaflets. Po carries a single immunoglobulin (Ig)-like domain that is stabilized by a disulfide bond between Cys21 and Cys98. We showed previously that Po mutated at Cys21 to Ala (C21A Po), unlike wild type Po, when it was expressed in Chinese hamster ovary (CHO) cells after transfection, was not...

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Identifiers

PMID: 9670987
DOI: 10.1002/(SICI)1097-4547(19980701)53:1<1::AID-JNR1>3.0.CO;2-F

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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