Article
Increased risk for venous thrombosis in carriers of the prothrombin G-->A20210 gene variant.
Annals of internal medicine - 15 Jul 1998
Margaglione M, Brancaccio V, Giuliani N, D'Andrea G, Cappucci G, Iannaccone L, Vecchione G, Grandone E, Di Minno G
Abstract excerpt
BACKGROUND: A mutation in the prothrombin gene (G-->A20210) has been associated with higher plasma prothrombin levels and an increased tendency for venous thrombosis. OBJECTIVE: To determine whether the prothrombin A20210 allele is independently associated with the occurrence of venous thrombosis...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Case-Control Studies
- Child
- Child, Preschool
- Factor V
- Female
- Heterozygote
- Humans
- Male
- Middle Aged
- Mutation
- Point Mutation
- Prothrombin
- Risk Factors