Article
A c-rasHa mutation in the metastasis of a human papillomavirus (HPV)-18 positive penile squamous cell carcinoma suggests a cooperative effect between HPV-18 and c-rasHa activation in malignant progression.
Cancer - 1 Jul 1998
Leis P F, Stevens K R, Baer S C, Kadmon D, Goldberg L H, Wang X J
Abstract excerpt
BACKGROUND: Human papillomaviruses (HPV) have been implicated in the etiology of anogenital squamous epithelial tumors. Of the 65 HPV strains, subtypes HPV-16 and HPV-18 frequently are associated with malignant conditions and are capable of transforming keratinocytes in vitro. However, additional...
Topics
- Carcinoma, Squamous Cell
- DNA, Viral
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Genes, ras
- Humans
- Keratins
- Male
- Middle Aged
- Mutation
- Papillomaviridae
- Penile Neoplasms