Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular biology of squamous cell carcinoma of the anus: a comparison of HIV-positive and HIV-negative patients.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract - 1 Dec 2004

Gervaz Pascal, Hahnloser Dieter, Wolff Bruce G, Anderson Sarah A, Cunningham Julie, Beart Robert W, Klipfel Adam, Burgart Lawrence, Thibodeau Stephen N

Abstract excerpt

The molecular mechanisms involved in progression of squamous cell carcinoma of the anus (SCCA) are poorly elucidated, as well as the potential role of HIV infection. Loss of heterozygosity (LOH) is one of the mechanisms responsible for inactivation of tumor suppressor genes. We hypothesized that HIV-induced immunosuppression may contribute to an alternate molecular pathway in SCCA progression, through persistence...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Anus Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Carcinoma, Squamous Cell

Share to Chromosome Mapping

Share to DCC gene

Share to HIV Seronegativity

Share to HIV Seropositivity

Share to Loss of Heterozygosity

Source

Identifiers

PMID: 15585390
DOI: 10.1016/j.gassur.2004.08.013

Genes

APC
DCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular biology of squamous cell carcinoma of the anus: a comparison of HIV-positive and HIV-negative patients.PMID 15585390Read ↗

Biology of HPV in HIV InfectionSemantic proximity Read ↗

Molecular biology of anal squamous cell carcinoma: implications for future research and clinical intervention.Semantic proximity Read ↗

HIV-Infected Patients With Anal Cancer Precursors: Clinicopathological Characteristics and Human Papillomavirus Subtype Distribution.Semantic proximity Read ↗

Comparison of Molecular Changes in Lung Cancers in HIV-Positive and HIV-Indeterminate SubjectsSemantic proximity Read ↗

Anal carcinoma in human immunodeficiency virus-positive men: results of a prospective study from Germany.Semantic proximity Read ↗

Distinct pattern of TP53 mutations in human immunodeficiency virus–related head and neck squamous cell carcinomaSemantic proximity Read ↗

Human papillomavirus, human immunodeficiency virus, and cervical cancer: newly recognized associations?Semantic proximity Read ↗

Cancer Risk Stratification of Anal Intraepithelial Neoplasia in Human Immunodeficiency Virus–Positive Men by Validated Methylation Markers Associated With Progression to CancerSemantic proximity Read ↗

HIVtat Alters Epithelial Differentiation State and Increases HPV16 Infectivity in Oral KeratinocytesSemantic proximity Read ↗

HPV-negative penile squamous cell carcinoma: disruptive mutations in the TP53 gene are common.Semantic proximity Read ↗

The Role of Cancer Biomarkers in HIV Infected Hosts.Semantic proximity Read ↗

HPV infection and EGFR activation/alteration in HIV-infected East African patients with conjunctival carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.