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Cerebellar long-term depression and auto-immune target of auto-antibodies: the concept of LTDpathies

10 Jan 2021

Abstract excerpt

There is general agreement that auto-antibodies against ion channels and synaptic machinery proteins can induce limbic encephalitis. In immune-mediated cerebellar ataxias (IMCAs), various synaptic proteins, such as GAD65, voltage-gated Ca channel (VGCC), metabotropic glutamate receptor type 1 (mGluR1), and glutamate receptor delta (GluR delta) are auto-immune targets. Among them, the pathophysiological mechanisms...

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PMID: 35006439
DOI: 10.1186/s43556-020-00024-x

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