Article
Limited variability of glycoprotein gene sequences and neutralizing targets in herpes simplex virus type 2 isolates and stability on passage in cell culture.
The Journal of infectious diseases - 1 Jul 1998
Terhune S S, Coleman K T, Sekulovich R, Burke R L, Spear P G
Abstract excerpt
Nucleotide sequence analyses of polymerase chain reaction-amplified genes were performed to determine whether adaptation of herpes simplex virus type 2 to replication in cultured cells or in internal organs during neonatal disseminated disease results in selection of variants with altered forms o...
Topics
- Adult
- Animals
- Antibodies, Viral
- Cell Line
- Chlorocebus aethiops
- Cricetinae
- Genes, Viral
- Genetic Variation
- Guinea Pigs
- Herpes Genitalis
- Herpesvirus 2, Human
- Humans
- Infant
- Neutralization Tests
- Sequence Analysis, DNA
- Serial Passage
- Tumor Cells, Cultured
- Vaccines, Synthetic