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Article

Hsp72-mediated augmentation of MHC class I surface expression and endogenous antigen presentation.

International immunology - 1 May 1998

Wells A D, Rai S K, Salvato M S, Band H, Malkovsky M

Abstract excerpt

Efficient recognition of tumor cells by cytolytic T lymphocytes (CTL) is often dependent on the presentation of cytosolic peptides in the context of MHC class I molecules. This process may be influenced by various molecular chaperones. To analyze this influence, we have utilized B16 melanoma cells, which are not effectively recognized by MHC class I-restricted CTL. This resistance to CTL is apparently due to a...

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PMID: 9645609
DOI: 10.1093/intimm/10.5.609

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