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Article

Chaperokine function of recombinant Hsp72 produced in insect cells using a baculovirus expression system is retained.

The Journal of biological chemistry - 1 Jan 2010

Zheng Hongying, Nagaraja Ganachari M, Kaur Punit, Asea Edwina E, Asea Alexzander

Abstract excerpt

Extracellular heat shock protein 72 (Hsp72; inducible form of the 70-kDa heat shock protein) plays a critical role in innate and adaptive immune responses and has shown promise as an ideal adjuvant for the optimization of antigen-specific anti-tumor vaccines. Recent studies suggest that to correctly elucidate the mechanisms by which Hsp72 exerts its beneficial effects in vitro, great care must be taken to ensure...

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PMID: 19861412
DOI: 10.1074/jbc.M109.024612
PMCID: PMC2804182

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