Article
Role of the C-terminal tryptophan residue for the structure-function of the alphavirus capsid protein.
Journal of molecular biology - 19 Jun 1998
Skoging U, Liljeström P
Abstract excerpt
The Semliki Forest virus capsid protein is a multifunctional protein which packages genomic RNA into nucleocapsid structures and binds to viral spike protein during budding. In addition, the capsid protein has an autoproteolytic activity whereby the C-terminal tryptophan is used as the substrate for cotranslational cleavage of the viral structure polyprotein. The autoproteolytic domain of the capsid protein has a...
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