Genomic disruption of six budding yeast genes gives one drastic example of phenotype strain-dependence.

Abstract excerpt

Using PCR to construct disruption cassettes, null alleles of six genes have been created in Saccharomyces cerevisiae. In a FY1679 background, no defects were detected in any of the haploid deletion mutants with respect to growth, gross morphology, or mating. A diploid FY1679-derived delta ygl194c/delta ygl194c homozygous disruptant displayed reduced sporulation. In contrast to the lack of phenotypic consequences...

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