Article
Podocyte phenotypes as defined by expression and distribution of GLEPP1 in the developing glomerulus and in nephrotic glomeruli from MCD, CNF, and FSGS. A dedifferentiation hypothesis for the nephrotic syndrome.
Experimental nephrology - 1 Jan 2000
Sharif K, Goyal M, Kershaw D, Kunkel R, Wiggins R
Abstract excerpt
Glomerular epithelial protein 1 (GLEPP1) is a podocyte receptor membrane protein tyrosine phosphatase located on the apical cell membrane of visceral glomerular epithelial cell (VGEC) foot processes. Double label immunofluorescence, immunoelectron microscopy, and peroxidase immunohistochemistry w...
Topics
- Animals
- Animals, Newborn
- Antibodies, Monoclonal
- Biomarkers
- Fluorescent Antibody Technique
- Glomerulosclerosis, Focal Segmental
- Humans
- Immunoenzyme Techniques
- Immunophenotyping
- Kidney Glomerulus
- Membrane Proteins
- Mice
- Microscopy, Immunoelectron
- Nephrosis, Lipoid