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Article

Tropomyosin implicated in host protective responses to microfilariae in onchocerciasis

23 Jun 1998

Abstract excerpt

A cDNA from adult female Onchocerca volvulus encoding the C-terminal portion of a tropomyosin isoform (termed MOv-14) has been shown previously to confer protective immunity in rodent models of onchocerciasis. The full-length sequence (designated Ov-tmy-1) obtained by PCR amplification, codes for a protein of 33 kDa and shares 91% identity with tropomyosins from other nematodes, falling to 57% identity with human...

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PMID: 9636187
DOI: 10.1073/pnas.95.13.7550

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