Comparative Evaluation of Culture and PCR for the Detection and Determination of Persistence of Bacterial Strains and DNAS in the Chinchilla Laniger Model of Otitis Media

Abstract excerpt

This study was designed to determine the persistence of culturable bacteria versus DNA in the presence of a middle ear effusion in a chinchilla model of otitis media. Cohorts of animals were either infected with an ampicillin-resistant Haemophilus influenzae strain or injected with a tripartite inoculum consisting of freeze-thawed Streptococcus pneumoniae; pasteurized Moraxella catarrhalis; and DNA from H...

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